Ongoing efforts to reduce direct and indirect emissions of commercial refrigeration systems include using leak reduction measures, refrigerant charge minimization, low global warming potential (GWP) refrigerants and energy efficiency measures. In this paper, Life Cycle Climate Performance (LCCP) analysis is used to estimate the lifetime carbon dioxide equivalent emissions of commercial refrigeration system designs and refrigerant options. Commercial refrigeration systems investigated in this study include the centralized direct expansion (DX) system with hydrofluorocarbon (HFC) and hydrofluoroolefin (HFO) refrigerant blends, the transcritical R-744 booster system, and self-contained systems using R-290. The results of the LCCP analysis are presented for a variety of cities around the world, and recommended systems and refrigerant options are provided based on direct and indirect carbon emissions.