The recent Kigali amendment to the Montreal Protocol has initiated regulatory and voluntary actions to limit the direct global warming potential (GWP) of refrigerants used in many applications, including chillers. This paper provides an update on the latest low GWP refrigerant technology for chiller applications. Low GWP refrigerant technology continues to evolve and innovation continues with the development of new refrigerants to replace R-123, R-245fa, R-134a and R-410A for chillers, many of which are ultra-low GWP (GWP <10). OEM’s continue to expand the introductions of R-1233zd(E), R-514A, R-513A, and R-1234ze(E) for large chiller products to replace R-123 and R-134a. R1224yd(Z) has recently been introduced to replace R-245fa. Several flammable R410A replacements, for example R-32 and R-452B have been previously reviewed, but a new nonflammable refrigerant, R-466A, will be compared to the above alternatives for use in R410A chillers.