A self-tuning semi-empirical model for the transient simulation of domestic refrigerators is presented in this paper. The model is based on a quasi-steady approach, where the time variations associated with the thermal inertia of the refrigerated compartments and heat exchangers are considered, whereas the refrigeration loop is modelled assuming steady-state conditions. The model was coded in Modelica and validated against experimental data obtained for two different refrigerator platforms namely, natural-draft all-refrigerator and fan-and-damper top-mount (Combi) refrigerator. Additionally, a self-tuning method was put forward to identify the values of the model closing parameters, such as conductances and thermal capacities. When compared with experimental data obtained in-house, an agreement between model predictions and experimental counterparts within ±10% error bands for the power consumption, and within ±1°C thresholds for the compartment air temperatures can be observed.